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KMID : 0606920160240030312
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Biomolecules & Therapeutics
2016 Volume.24 No. 3 p.312 ~ p.319
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Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes
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Hewage Susara Ruwan Kumara Madduma
Piao Mei Jing
Kang Kyoung-Ah
Ryu Yea-Seong
Han Xia
Oh Min-Chang
Jung U-Hee
Kim In-Gyu
Hyun Jin-Won
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Abstract
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Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin (C28H34O15) to prevent apoptosis due to oxidative stress generated through UVB-induced ROS. Hesperidin significantly scavenged ROS generated by UVB radiation, attenuated the oxidation of cellular macromolecules, established mitochondrial membrane polarization, and prevented the release of cytochrome c into the cytosol. Hesperidin downregulated expression of caspase-9, caspase-3, and Bcl-2-associated X protein, and upregulated expression of B-cell lymphoma 2. Hesperidin absorbed wavelengths of light within the UVB range. In summary, hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis via its antioxidant and UVB absorption properties.
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KEYWORD
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Apoptosis, Antioxidant, Hesperidin, Reactive oxygen species, Ultraviolet B
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